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Tecan无限 ^®m1000多模微版阅读器 帮助科学家 细胞生物解剖系 时间点佐治亚卫生大学开发高吞吐系统,用于活斑马病模型中以报告者为基础的药物筛测 ^一号.GGSU助理教授Jeff Mum博士解释道:“量化微版阅读器系统使药物发现速度发生翻天覆地变化, 试管内并 里科允许高通量筛选的解析生物验证成为药物发现过程的瓶颈,原因是缺少HTS兼容性 维沃解析平台量化报告维生斑马鱼提供多功能工具 来缓解路段

无限M1000使我们开发出简单高成本效益自动筛选法 基础是活斑马鱼检测荧光或发光报告器Using this method we have been able to quantify the loss and regeneration of targeted cells in zebrafish disease models, as well as small molecule-induced changes in disease-linked molecular signaling pathways. High signal to noise ratios allow us to monitor changes in individual fish - which accounts for wide reporter level variance across populations by normalizing signals to each individual's ground state - enabling us to detect long-term changes over several days. This powerful technique will benefit a wide variety of high throughput chemical and genetic screens in live zebrafish, potentially accelerating the validation of new drugs."

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沃克SLet al.自动化报告员量化维沃市高通量筛选法PLOS一2012年1月4日发布